InsiderTrades

Form 4 for BCYC BICYCLE THERAPEUTICS PLC

Accepted 2026-01-06 00:00:00 ET · period of report 2026-01-02 · accession 0001193125-26-004828 · SEC index · Original document

Summary rows

Aggregated the way they appear in lists: one row per insider, transaction code and security table.

X Filed Traded Ticker Insider Title Type Price Qty Owned ΔOwn Value
DMI 2026-01-06 2026-01-02 BCYC BAKER FELIX Dir, 10% A - Grant $0.00 +38.0K 937.5K +4% $0
DMI 2026-01-06 2026-01-02 BCYC BAKER FELIX Dir, 10% A - Grant $0.00 +76.0K 38.0K New $0

Purchase Sale Sale after option exercise All abbreviations

Every reported transaction

#TableSecurityDateCodeA/DSharesPriceOwned afterOwnExercise / expiryUnderlyingFootnotes
1 Common American Depositary Shares 2026-01-02 A A 19,000 $0.00 10,018,674 I See Footnotes — — (F1) Includes 19,000 restricted share units (each an "RSU") payable in American Depositary Shares ("ADS") or Ordinary Shares ("Ordinary Shares") at the option of Bicycle Therapeutics plc (the "Issuer") granted by the Issuer to Felix J. Baker, a managing member of Baker Bros. Advisors (GP) LLC (the "Adviser GP") on January 2, 2026 pursuant to the Issuer's 2020 Equity Incentive Plan (the "2020 Plan"). The RSUs vest in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, subject to Felix J. Baker's continuous service on the board of directors of the Issuer (the "Board") through such vesting dates. Felix J. Baker serves on the Board as a representative of 667, L.P. ("667") and Baker Brothers Life Sciences, L.P. ("Life Sciences", and together with 667, the "Funds"). Each RSU represents a contingent right to receive one ADS or Ordinary Share. (F9) After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Brothers Life Sciences Capital, L.P. and (ii) Life Sciences, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the securities reported in column 5 of Table I and in column 9 of Table II directly held by or held for the benefit of Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to their interest in Life Sciences and Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences. (F4) Baker Bros. Advisors LP ("the Adviser") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. (F2) ADS each represent 1 Ordinary Share. (F7) Pursuant to the policies of the Adviser, Felix J. Baker does not have any right to any of the Issuer's securities issued as compensation for his service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs and non-qualified share options exercisable into ADS or Ordinary Shares of the Issuer ("Share Options") received as a result of his service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs, Share Options, and ADS or Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest) issued as compensation for such Board service. (F5) Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose. (F6) Includes beneficial ownership of 16,400 ADS issuable upon the vesting of RSUs payable in ADS or Ordinary Shares at the Issuer's option previously issued to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan of which the Funds may be deemed to own a portion. 8,400 of the RSUs previously granted are fully vested and the remaining 8,000 vest in two equal annual installments beginning on April 18, 2026, subject to Felix J. Baker's continuous service on the Board through the vesting date. Felix J. Baker serves on the Board as a representative of the Funds and their affiliates and control persons. Each RSU represents a contingent right to receive one Ordinary Share of the Issuer. (F8) The Adviser has voting and dispositive power over the Share Options, RSUs and any ADS or Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs.
2 Common American Depositary Shares 2026-01-02 A A 19,000 $0.00 937,483 I See Footnotes — — (F1) Includes 19,000 restricted share units (each an "RSU") payable in American Depositary Shares ("ADS") or Ordinary Shares ("Ordinary Shares") at the option of Bicycle Therapeutics plc (the "Issuer") granted by the Issuer to Felix J. Baker, a managing member of Baker Bros. Advisors (GP) LLC (the "Adviser GP") on January 2, 2026 pursuant to the Issuer's 2020 Equity Incentive Plan (the "2020 Plan"). The RSUs vest in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, subject to Felix J. Baker's continuous service on the board of directors of the Issuer (the "Board") through such vesting dates. Felix J. Baker serves on the Board as a representative of 667, L.P. ("667") and Baker Brothers Life Sciences, L.P. ("Life Sciences", and together with 667, the "Funds"). Each RSU represents a contingent right to receive one ADS or Ordinary Share. (F4) Baker Bros. Advisors LP ("the Adviser") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. (F2) ADS each represent 1 Ordinary Share. (F7) Pursuant to the policies of the Adviser, Felix J. Baker does not have any right to any of the Issuer's securities issued as compensation for his service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs and non-qualified share options exercisable into ADS or Ordinary Shares of the Issuer ("Share Options") received as a result of his service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs, Share Options, and ADS or Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest) issued as compensation for such Board service. (F3) After giving effect to the transactions reported herein and as a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the securities reported in column 5 of Table I and in column 9 of Table II directly held by or held for the benefit of 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667. (F5) Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose. (F6) Includes beneficial ownership of 16,400 ADS issuable upon the vesting of RSUs payable in ADS or Ordinary Shares at the Issuer's option previously issued to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan of which the Funds may be deemed to own a portion. 8,400 of the RSUs previously granted are fully vested and the remaining 8,000 vest in two equal annual installments beginning on April 18, 2026, subject to Felix J. Baker's continuous service on the Board through the vesting date. Felix J. Baker serves on the Board as a representative of the Funds and their affiliates and control persons. Each RSU represents a contingent right to receive one Ordinary Share of the Issuer. (F8) The Adviser has voting and dispositive power over the Share Options, RSUs and any ADS or Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs.
3 Derivative Share Option (Right to Buy) 2026-01-02 A A 38,000 $0.00 38,000 I See Footnotes $7.08 · — to 2036-01-02 38,000 American Depositary Shares (F10) Includes 38,000 Share Options granted by the Issuer to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan. The Share Options have a strike price of $7.08 and vest into ADS or Ordinary shares at the Issuer's option in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise. (F11) The acquisitions of the RSUs and Share Options reported on this form represent a single grant to Felix J. Baker of 19,000 RSUs on Table I and 38,000 Share Options on Table II. These grants, totaling 19,000 RSUs and 38,000 Share Options for Felix J. Baker, are reported for each of the Funds as each has an indirect pecuniary interest in such securities. (F4) Baker Bros. Advisors LP ("the Adviser") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. (F7) Pursuant to the policies of the Adviser, Felix J. Baker does not have any right to any of the Issuer's securities issued as compensation for his service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs and non-qualified share options exercisable into ADS or Ordinary Shares of the Issuer ("Share Options") received as a result of his service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs, Share Options, and ADS or Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest) issued as compensation for such Board service. (F3) After giving effect to the transactions reported herein and as a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the securities reported in column 5 of Table I and in column 9 of Table II directly held by or held for the benefit of 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667. (F5) Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose. (F8) The Adviser has voting and dispositive power over the Share Options, RSUs and any ADS or Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs.
4 Derivative Share Option (Right to Buy) 2026-01-02 A A 38,000 $0.00 38,000 I See Footnotes $7.08 · — to 2036-01-02 38,000 American Depositary Shares (F10) Includes 38,000 Share Options granted by the Issuer to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan. The Share Options have a strike price of $7.08 and vest into ADS or Ordinary shares at the Issuer's option in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise. (F9) After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Brothers Life Sciences Capital, L.P. and (ii) Life Sciences, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the securities reported in column 5 of Table I and in column 9 of Table II directly held by or held for the benefit of Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to their interest in Life Sciences and Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences. (F11) The acquisitions of the RSUs and Share Options reported on this form represent a single grant to Felix J. Baker of 19,000 RSUs on Table I and 38,000 Share Options on Table II. These grants, totaling 19,000 RSUs and 38,000 Share Options for Felix J. Baker, are reported for each of the Funds as each has an indirect pecuniary interest in such securities. (F4) Baker Bros. Advisors LP ("the Adviser") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. (F7) Pursuant to the policies of the Adviser, Felix J. Baker does not have any right to any of the Issuer's securities issued as compensation for his service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs and non-qualified share options exercisable into ADS or Ordinary Shares of the Issuer ("Share Options") received as a result of his service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs, Share Options, and ADS or Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest) issued as compensation for such Board service. (F5) Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose. (F8) The Adviser has voting and dispositive power over the Share Options, RSUs and any ADS or Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs.