Form 4 for SEPN Septerna, Inc.
Accepted 2026-03-04 00:00:00 ET · period of report 2026-03-02 · accession 0001193125-26-092050 · SEC index · Original document
Summary rows
Aggregated the way they appear in lists: one row per insider, transaction code and security table.
| X | Filed | Traded | Ticker | Insider | Title | Type | Price | Qty | Owned | ΔOwn | Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| DMT | 2026-03-04 | 2026-03-02 | SEPN | Shaikhly Samira | CHRO | S - Sale+OE | $28.10 | -70.5K | 67.2K | -51% | -$1.98M |
| DMT | 2026-03-04 | 2026-03-02 | SEPN | Shaikhly Samira | CHRO | M - OptEx | $1.84 | +70.5K | 54.5K | New | +$129.5K |
| DMT | 2026-03-04 | 2026-03-02 | SEPN | Shaikhly Samira | CHRO | M - OptEx | $0.00 | -70.5K | 3,460 | -95% | $0 |
Purchase Sale Sale after option exercise All abbreviations
Every reported transaction
| # | Table | Security | Date | Code | A/D | Shares | Price | Owned after | Own | Exercise / expiry | Underlying | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Common | Common Stock | 2026-03-02 | S | D | 66,363 | $28.14 | 793 | D | — | — | (F4) The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $27.90 to $28.70. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. |
| 2 | Common | Common Stock | 2026-03-02 | S | D | 4,090 | $27.51 | 67,156 | D | — | — | (F3) The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $26.90 to $27.89. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. |
| 3 | Common | Common Stock | 2026-03-02 | M | A | 5,101 | $2.76 | 71,246 | D | — | — | |
| 4 | Common | Common Stock | 2026-03-02 | M | A | 11,638 | $2.76 | 66,145 | D | — | — | |
| 5 | Common | Common Stock | 2026-03-02 | M | A | 53,714 | $1.55 | 54,507 | D | — | — | (F1) Includes 793 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on October 31, 2025 in a transaction that was exempt under Rule 16b-3(c). |
| 6 | Derivative | Stock Option (Right to Buy) | 2026-03-02 | M | D | 53,714 | $0.00 | 15,969 | D | $1.55 · — to 2033-03-30 | 53,714 Common Stock | (F5) 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date. |
| 7 | Derivative | Stock Option (Right to Buy) | 2026-03-02 | M | D | 5,101 | $0.00 | 5,101 | D | $2.76 · — to 2034-03-19 | 5,101 Common Stock | (F6) 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date. |
| 8 | Derivative | Stock Option (Right to Buy) | 2026-03-02 | M | D | 11,638 | $0.00 | 3,460 | D | $2.76 · — to 2033-11-11 | 11,638 Common Stock | (F5) 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date. |