Form 4 for ALNY ALNYLAM PHARMACEUTICALS, INC.
Accepted 2025-11-14 00:00:00 ET · period of report 2025-11-12 · accession 0001735276-25-000120 · SEC index · Original document
Summary rows
Aggregated the way they appear in lists: one row per insider, transaction code and security table.
| X | Filed | Traded | Ticker | Insider | Title | Type | Price | Qty | Owned | ΔOwn | Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| DM | 2025-11-14 | 2025-11-12+ | ALNY | Greenstreet Yvonne | CEO, Dir | S - Sale+OE | $452.75 | -25.6K | 74.2K | -26% | -$11.61M |
| DM | 2025-11-14 | 2025-11-12+ | ALNY | Greenstreet Yvonne | CEO, Dir | M - OptEx | $117.18 | +25.6K | 81.1K | +46% | +$3.01M |
| DM | 2025-11-14 | 2025-11-12+ | ALNY | Greenstreet Yvonne | CEO, Dir | M - OptEx | $0.00 | -25.6K | 10.0K | -72% | $0 |
Purchase Sale Sale after option exercise All abbreviations
Every reported transaction
| # | Table | Security | Date | Code | A/D | Shares | Price | Owned after | Own | Exercise / expiry | Underlying | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Common | Common Stock | 2025-11-12 | S | D | 2,420 | $456.64 | 66,443 | D | — | — | (F10) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $456.22 to $457.19. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 2 | Common | Common Stock | 2025-11-12 | S | D | 3,406 | $455.56 | 68,863 | D | — | — | (F9) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $455.17 to $456.15. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 3 | Common | Common Stock | 2025-11-12 | S | D | 430 | $458.42 | 65,409 | D | — | — | (F12) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $458.37 to $458.56. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 4 | Common | Common Stock | 2025-11-13 | M | A | 10,000 | $119.13 | 75,409 | D | — | — | |
| 5 | Common | Common Stock | 2025-11-13 | S | D | 654 | $447.73 | 74,755 | D | — | — | (F13) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $447.30 to $448.24. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 6 | Common | Common Stock | 2025-11-13 | S | D | 1,013 | $448.76 | 73,742 | D | — | — | (F14) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $448.38 to $449.31. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 7 | Common | Common Stock | 2025-11-13 | S | D | 1,477 | $450.02 | 72,265 | D | — | — | (F15) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $449.50 to $450.50. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 8 | Common | Common Stock | 2025-11-13 | S | D | 2,218 | $450.69 | 70,047 | D | — | — | (F16) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $450.56 to $451.50. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 9 | Common | Common Stock | 2025-11-13 | S | D | 1,702 | $451.94 | 68,345 | D | — | — | (F17) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $451.60 to $452.31. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 10 | Common | Common Stock | 2025-11-13 | S | D | 1,599 | $452.85 | 66,746 | D | — | — | (F18) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $452.51 to $453.50. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 11 | Common | Common Stock | 2025-11-13 | S | D | 881 | $453.99 | 65,865 | D | — | — | (F19) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $453.55 to $454.46. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 12 | Common | Common Stock | 2025-11-13 | S | D | 195 | $454.69 | 65,670 | D | — | — | |
| 13 | Common | Common Stock | 2025-11-13 | S | D | 261 | $456.03 | 65,409 | D | — | — | |
| 14 | Common | Common Stock | 2025-11-12 | S | D | 604 | $457.71 | 65,839 | D | — | — | (F11) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $457.24 to $458.06. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 15 | Common | Common Stock | 2025-11-12 | S | D | 1,960 | $454.84 | 72,269 | D | — | — | (F8) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $454.16 to $455.16. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 16 | Common | Common Stock | 2025-11-12 | M | A | 650 | $42.22 | 66,059 | D | — | — | |
| 17 | Common | Common Stock | 2025-11-12 | M | A | 15,000 | $119.13 | 81,059 | D | — | — | |
| 18 | Common | Common Stock | 2025-11-12 | S | D | 711 | $448.07 | 80,348 | D | — | — | (F2) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $447.67 to $448.67. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 19 | Common | Common Stock | 2025-11-12 | S | D | 2,132 | $449.15 | 78,216 | D | — | — | (F3) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $448.69 to $449.69. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 20 | Common | Common Stock | 2025-11-12 | S | D | 453 | $450.17 | 77,763 | D | — | — | (F4) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $449.72 to $450.64. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 21 | Common | Common Stock | 2025-11-12 | S | D | 1,255 | $451.16 | 76,508 | D | — | — | (F5) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $450.75 to $451.55. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 22 | Common | Common Stock | 2025-11-12 | S | D | 1,210 | $452.43 | 75,298 | D | — | — | (F6) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $451.95 to $452.89. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 23 | Common | Common Stock | 2025-11-12 | S | D | 1,069 | $453.52 | 74,229 | D | — | — | (F7) The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $453.14 to $454.11. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| 24 | Derivative | Performance Stock Option 2016 (right to buy) | 2025-11-12 | M | D | 650 | $0.00 | 0 | D | $42.22 · 2019-08-06 to 2026-12-20 | 650 Common Stock | (F21) This stock option was fully vested and exercisable as of August 6, 2019. |
| 25 | Derivative | Performance Stock Option 2017 (right to buy) | 2025-11-13 | M | D | 10,000 | $0.00 | 0 | D | $119.13 · 2021-02-11 to 2028-03-01 | 10,000 Common Stock | (F22) This stock option was fully vested and exercisable as of February 11, 2021. |
| 26 | Derivative | Performance Stock Option 2017 (right to buy) | 2025-11-12 | M | D | 15,000 | $0.00 | 10,000 | D | $119.13 · 2021-02-11 to 2028-03-01 | 15,000 Common Stock | (F22) This stock option was fully vested and exercisable as of February 11, 2021. |